An influence of androgen receptor (AR) gene СAG-polymorphism on spermatogenesis in infertile men

We analyzed the results of semen examination in 200 infertile men with various numbers of GAG-repeats in the exon 1 of the androgen receptor (AR) gene. The number of repeats ranged from 7 to 31, the average number of repeats was 22.2 ± 1.6, with the most common variant (13 %) present 21 repeats. Our findings confirm that of AR gene СAG-polymorphism can an effect on sperm parameters and male fertility. The spermatogenesis can be impaired in infertile men with “short” CAG-repeats not less than with “long” CAG-repeats.

androgen receptor, AR gene, СAG-polymorphism, male infertility, spermatogenesis

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