agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2023-24-4-59-66agx-705Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWМесто антиоксидантов в терапии мужского бесплодияThe place of antioxidants in male infertility therapyhttps://orcid.org/0009-0004-8370-4392ГвасалияБ. Р.GvasaliaB. R.

Бадри Роинович Гвасалия

127473 Москва, ул. Делегатская, 20, стр. 1

125080 Москва, Волоколамское шоссе, 11

Badri Roinovich Gvasalia

Bld. 1, 20 Delegatskaya St., Moscow 127473

11, Volokolamskoe Shosse, Moscow 125080

bgvasalia@gmail.comhttps://orcid.org/0009-0008-9223-9460ИсаеваА. В.IsaevaA. V.

127473 Москва, ул. Делегатская, 20, стр. 1

Bld. 1, 20 Delegatskaya St., Moscow 127473

https://orcid.org/0000-0001-6654-9280БабаевМ. У.BabaevM. U.

127473 Москва, ул. Делегатская, 20, стр. 1

Bld. 1, 20 Delegatskaya St., Moscow 127473

Кафедра урологии ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; кафедра урологии Московского института непрерывного образования ФГБОУ ВО «Российский биотехнологический университет (РОСБИОТЕХ)»РоссияDepartment of Urology, A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Department of Urology of the Moscow Institute of Continuing Education, Russian Biotechnological University (ROSBIOTECH)Russian FederationКафедра урологии ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияDepartment of Urology, A.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation2023281120232445966Copyright © Гвасалия Б.Р., Исаева А.В., Бабаев М.У., 20232023Гвасалия Б.Р., Исаева А.В., Бабаев М.У.Gvasalia B.R., Isaeva A.V., Babaev M.U.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/705

Проблема бесплодия затрагивает от 10 до 15 % пар во всем мире. На долю мужского фактора приходится до половины всех случаев бесплодия, при этом от 25 до 87 % случаев мужского бесплодия, как предполагают, обусловлены влиянием оксидативного стресса. Избыточная концентрация активных форм кислорода приводит к повреждению мембран сперматозоидов и нарушению целостности их ДНК, что отражается не только на вероятности наступления беременности естественным путем, но и на результатах применения вспомогательных репродуктивных технологий и риске невынашивания беременности. В данной работе представлен обзор экзогенных и эндогенных факторов антиоксидантной защиты, а также данные об их влиянии на параметры спермы и репродуктивное здоровье мужчин в целом.

Infertility affects 10 to 15 % of couples worldwide. Male factor accounts for up to half of infertility cases, with 25 to 87 % of male infertility cases thought to be caused by oxidative stress. Excessive concentrations of reactive oxygen species lead to damage to sperm membranes and disruption of the integrity of their DNA, which affects not only the likelihood of pregnancy naturally, but also the results of using assisted reproductive technologies and the risk of miscarriage. This paper provides an overview of exogenous and endogenous antioxidant protection factors, as well as their impact on sperm parameters and male reproductive health in general.

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The authors declare that there are no conflicts of interest present.