agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2013-4-45-48agx-69Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL REPORTВлияние TGF-β1 и VEGF на процессы ангио- и нефрогенезаTGF-β1 and VEGF influence on angio- and nephrogenesis processesСевергинаЛюбовь ОлеговнаSeverginaL. O.

Кафедра патологической анатомии

Department of Morbid Anatomy

losevergina@gmail.comСевергинаЭ. С.SeverginaE. S.

Кафедра патологической анатомии

Department of Morbid Anatomy

losevergina@gmail.comЛеоноваЛ. В.LeonovaL. V.

кафедра патологической анатомии педиатрического факультета, Москва

Department of Morbid Anatomy, Faculty of Pediatrics, Moscow

losevergina@gmail.comРапопортЛ. М.RapoportL. M.

кафедра урологии

Department of Urology

losevergina@gmail.comГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian FederationГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation2013301120141444548Copyright © Севергина Л.О., Севергина Э.С., Леонова Л.В., Рапопорт Л.М., 20142014Севергина Л.О., Севергина Э.С., Леонова Л.В., Рапопорт Л.М.Severgina L.O., Severgina E.S., Leonova L.V., Rapoport L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/69

На светооптическом и иммуногистохимическом уровнях изучены биоптаты почек детей с врожденным гидронефрозом в возрасте от 3 дней до 12 лет, полученные при нефрэктомии, с целью установления влияния факторов роста на процессы васкуляризации почки и созревания почечной ткани. Показано, что слабая экспрессия VEGF при более выраженной экспрессии TGF-β1 и его рецепторов – R1 и R2 – на различных структурах нефункционирующих или гипопластических почек у детей раннего возраста может быть критерием нарушенного ангио- и нефрогенеза.

Kidney biopsies obtained from 3 days – 12 years children with congenital hydronephrosis during nephrectomy operation were investigated under the light microscopy in our study. Also we did immunohistochemical reactions. The aim of our study was to reveal the growth factor influence on maturation and vascularisation of kidney parenchyma. We showed, that the low VEGF expression in association with higher expression of TGF-β1 and its receptors – R1 and R2 – on different structures of nonfunctioning or hypoplastic kidneys in children might be a criterion of abnormal angio- and nephrogenesis.

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The authors declare that there are no conflicts of interest present.