agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2013-4-36-44agx-68Research ArticleОБЗОРНЫЕ СТАТЬИREVIEWВитамин D, мужское здоровье и мужская репродукцияVitamin D, men's health and male reproductionТюзиковИгорь АдамовичTyuzikovI. A.

Ярославль

Yaroslavl

phoenix-67@list.ruКалинченкоС. Ю.KalinchenkoS. Yu.

кафедра эндокринологии, Москва

Department of Endocrinology, Faculty for Postgraduate Training of Medical Workers, Moscow

phoenix-67@list.ruВорсловЛ. О.VorslovL. O.

кафедра эндокринологии, Москва

Department of Endocrinology, Faculty for Postgraduate Training of Medical Workers, Moscow

phoenix-67@list.ruТишоваЮ. А.TishovaYu. A.

кафедра эндокринологии, Москва

Department of Endocrinology, Faculty for Postgraduate Training of Medical Workers, Moscow

phoenix-67@list.ruООО «Медицинский центр диагностики и профилактики»РоссияOOO Medical Diagnosis and Prevention CenterRussian FederationФПК МР ФГБОУ ВПО РУДНРоссияPeoples’ Friendship University of RussiaRussian Federation2013291120141443644Copyright © Тюзиков И.А., Калинченко С.Ю., Ворслов Л.О., Тишова Ю.А., 20142014Тюзиков И.А., Калинченко С.Ю., Ворслов Л.О., Тишова Ю.А.Tyuzikov I.A., Kalinchenko S.Y., Vorslov L.O., Tishova Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/68

В литературном обзоре представлены современные данные, доказывающие важную физиологическую роль витамина D и его дефицита для мужского здоровья в целом и мужской репродукции в частности. На сегодняшний день эти доказательства базируются в основном на экспериментальных работах с животными и на клинических наблюдательных исследованиях, доказательная база которых пока недостаточна для формулировки общей концепции дефицита витамина D в современной репродуктологии. Однако, учитывая высокую распространенность мужского бесплодия, недиагностированного андрогенного дефицита и дефицита витамина D, находящихся между собой в теснейших достоверных патофизиологических связях, можно предположить, что дальнейшие исследования в области эндокринологии витамина D могут привести к появлению новых методов оценки мужской репродуктивной функции и разработке новых патогенетических терапевтических подходов к лечению мужского бесплодия. Эти перспективы особенно важны, если учесть, что бесплодием страдают не менее 10–20 % супружеских пар, и эта цифра постоянно увеличивается. Несмотря на то что витамин D пока не входит в перечень препаратов для лечения мужского бесплодия, его влияние на андрогенный статус мужчины, являющийся эндокринологическим базисом половой и репродуктивной функций, и позитивные эффекты на сперматогенез в экспериментальных исследованиях следует считать доказанными. Кроме того, необходимы крупномасштабные клинические рандомизированные исследования для определения оптимального физиологического уровня 25(OH)-витамина D для профилактики и лечения нарушений мужской фертильности.

In the literary review the modern data proving an important physiological role of vitamin D and its deficiency for man's health in whole and the male reproduction, in particular is presented. For today these proofs are based basically on experimental works with animals and on clinical observant researches which demonstrative base while is insufficient for a formulation of the general concept of vitamin D deficiency for modern medicine. However, there are some encouraging results deserving a complex estimation and the further basic researches. Considering high prevalence of male infertility, not diagnosed androgen deficiency and vitamin D at men, which have intime authentic pathophysiological communications, it is possible to assume that the further researches in area endocrinology of vitamin D can come to new methods of an estimation of men's reproductive function and working out of new pathogenetic therapeutic approaches in male infertility treatment. These prospects are especially important if to consider that infertility suffers not less than 10–20 % of married couples, and this figure constantly increases. In spite of the fact that vitamin D is not included yet into the list of preparations for treatment of male infertility, but its influence at male androgen status which is endocrinological basis of sexual and reproductive functions, and positive effects at spermatogenesis in experimental researches is necessary to consider proved. Besides, large-scale clinical randomized researches are necessary for definition of an optimal 25(OH)-vitamin D level for prevention and treatment of male fertility's disorders.

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The authors declare that there are no conflicts of interest present.