agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2023-24-2-66-76agx-662Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWОкситоцин – незаслуженно забытый гормон у мужчин?Is oxytocin an undeservedly forgotten hormone in men?https://orcid.org/0000-0001-6316-9020ТюзиковИ. А.TyuzikovI. A.

Игорь Адамович Тюзиков

150000 Ярославль, Первомайский переулок, 3в

Igor A. Tyuzikov 

3v Pervomaiskiy Ln., Yaroslavl 150000

phoenix-67@list.ruГрековЕ. А.GrekovE. A.

123022 Москва, улица 1905 года, 23

23 1905 Goda St., Moscow 123022

СмирновА. В.SmirnovA. V.

197110 Санкт-Петербург, пр-кт Динамо, 3

3 Dynamo Ave., St. Petersburg 197110

Медицинский центр «Тандем-Плюс»РоссияMedical Center “Tandem-Plus”Russian FederationКлиника “Hormone Life”Россия“Hormone Life” ClinicRussian FederationСПб ГБУЗ «Городская клиническая больница № 31»РоссияSaint Petersburg City Clinical Hospital No. 31Russian Federation2023200620232426676Copyright © Тюзиков И.А., Греков Е.А., Смирнов А.В., 20232023Тюзиков И.А., Греков Е.А., Смирнов А.В.Tyuzikov I.A., Grekov E.A., Smirnov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/662

Окситоцин – один из наиболее древних с точки зрения филогенеза гормонов млекопитающих. За более чем 100-летнюю историю его научного изучения взгляды на биологические функции окситоцина у человека претерпели существенные и даже революционные изменения. Длительное время этот гормон нейрогипофиза, который образуется в гипоталамусе и только депонируется в нем (центральный синтез), ассоциировался исключительно с женской репродукцией в аспекте родовой деятельности, грудного вскармливания и материнского поведения. Однако за последние десятилетия создана уникальная и обширная научная база, подтверждающая универсальный характер эффектов окситоцина у обоих полов, что предопределяется наличием у мужчин и женщин дополнительных периферических сайтов секреции окситоцина, а также обширного рецепторного аппарата во многих клетках и тканях, что в совокупности позволяет окситоцину функционировать как по эндокринному (центральному), так и по ауто- и паракринному (локальному) сигнальным путям. Этот факт убедительно доказывает наличие у окситоцина гораздо более широкого спектра физиологических эффектов в организме обоих полов, а результаты современных исследований позволяют рассматривать его как центральный нейропептид и периферический полифункциональный гормон, имеющий большое биологическое и социальное значение для человека.

В обзорной статье кратко рассматриваются эндокринология окситоцина и более подробно – его физиологические эффекты у мужчин, включая роль в социальном и половом поведении, обеспечении эректильной функции, защите от стресса, репродукции, метаболизме, функционировании предстательной железы.

Oxytocin is one of the most ancient mammalian hormones in terms of phylogeny. Over the more than 100-year history of his scientific study, views on the biological functions of oxytocin in humans have undergone a significant and even revolutionary changes. For a long time, this neurohypophysis hormone, which is formed in the hypothalamus and is only deposited in it (central synthesis), was associated exclusively with female reproduction in the aspect of labor, breastfeeding and maternal behavior. However, over the past decades, a unique and extensive scientific base has been created confirming the universal nature of the effects of oxytocin in both sexes, which is predetermined by the presence of additional peripheral sites of oxytocin secretion in men and women, as well as an extensive receptor apparatus in many cells and tissues, which together allows oxytocin to function both endocrine central and auto- and paracrine local signaling pathways. This fact convincingly proves that oxytocin has a much wider range of physiological effects in the body of both sexes, and the results of modern research allow us to consider it as a central neuropeptide and a peripheral multifunctional hormone of great biological and social significance for humans.

The review article briefly discusses the endocrinology of oxytocin and in more detail its physiological effects in men, including its role in social and sexual behavior, erectile function, protection from stress, reproduction, metabolism, prostate gland.

 

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The authors declare that there are no conflicts of interest present.