agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2022-23-4-81-89agx-619Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL REPORTПараметры спермограммы у мужчин – носителей робертсоновских транслокаций (13;14)Semen parameters in male carriers of Robertsonian translocations (13;14)https://orcid.org/0000-0002-5048-5486АндрееваМ. В.AndreevaM. V.

115522 Москва, ул. Москворечье, 1

1 Moskvorech’e St., Moscow 115522

https://orcid.org/0000-0003-3603-4838КурилоЛ. Ф.KuriloL. F.

115522 Москва, ул. Москворечье, 1

1 Moskvorech’e St., Moscow 115522

https://orcid.org/0000-0002-0580-5575ШтаутМ. И.ShtautM. I.

115522 Москва, ул. Москворечье, 1

1 Moskvorech’e St., Moscow 115522

https://orcid.org/0000-0002-7032-0793СедоваА. О.SedovaA. O.

115522 Москва, ул. Москворечье, 1

1 Moskvorech’e St., Moscow 115522

https://orcid.org/0000-0002-4618-2466СорокинаТ. М.SorokinaT. M.

115522 Москва, ул. Москворечье, 1

1 Moskvorech’e St., Moscow 115522

https://orcid.org/0000-0002-7615-8512ЧерныхВ. Б.ChernykhV. B.

Вячеслав Борисович Черных

115522 Москва, ул. Москворечье, 1

Vyacheslav Borisovich Chernykh 

1 Moskvorech’e St., Moscow 115522

chernykh@med-gen.ruФГБНУ «Медико-генетический научный центр им. акад. Н.П. Бочкова»РоссияN.P. Bochkov Research Centre for Medical GeneticsRussian Federation2022090120232348189Copyright © Андреева М.В., Курило Л.Ф., Штаут М.И., Седова А.О., Сорокина Т.М., Черных В.Б., 20232023Андреева М.В., Курило Л.Ф., Штаут М.И., Седова А.О., Сорокина Т.М., Черных В.Б.Andreeva M.V., Kurilo L.F., Shtaut M.I., Sedova A.O., Sorokina T.M., Chernykh V.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/619Введение

Введение. Робертсоновские транслокации (РТ) являются наиболее распространенным типом сбалансированных хромосомных аномалий. Мужчины – носители РТ имеют повышенный риск нарушений репродукции, однако причины этого недостаточно изучены.

Цель исследования – оценить параметры спермограммы у мужчин – носителей РТ (13;14).

Материалы и методы

Материалы и методы. Обследованы 24 мужчины с кариотипом 45,XY,der(13;14)(q10;q10), обратившихся в связи с бесплодием в браке (n = 23) или привычным невынашиванием беременности у супруги (n = 1). Результаты. У 18 (75 %) пациентов выявлена олигоастенотератозооспермия, у 3 (13 %) пациентов – астенотератозооспермия, у 2 (8 %) – азооспермия. Нормозооспермия диагностирована только у 1 (4 %) пациента, у него в анамнезе – привычное невынашивание беременности у супруги.

Выводы

Выводы. Бесплодие у обследованных мужчин – носителей РТ связано с нарушением сперматогенеза, у большинства пациентов приводящим к олигоастенотератозооспермии.

Background

Background. Robertsonian translocations (RTs) are the most common type of balanced chromosomal abnormalities. RT male carriers have an increased risk of reproductive disorders, but the causes of this still are not clear enough.

Aim

Aim. To evaluate semen parameters in RT(13;14) male carriers.

Materials and methods

Materials and methods. 24 men with 45,XY,der(13;14)(q10;q10) karyotype and infertility (n = 23) or recurrent pregnancy loss in spouse (n = 1).

Results

Results. Oligoasthenoteratozoospermia was detected in 18 (75 %) patients, asthenoteratozoospermia in 3 (13 %) patients, and azoospermia in 2 (8 %) patients. Normozoospermia was detected in 1 (4 %) patient, whose wife had a history of recurrent pregnancy loss.

Conclusion

Conclusion. Infertility in the examined RT male carriers is associated with spermatogenesis disorders, in most cases resulted in oligozooasthenoteratozoospermia.

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The authors declare that there are no conflicts of interest present.