agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-8902MedINK Publishing House LLC10.17650/2070-9781-2022-23-3-19-28agx-581Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWМеханизмы окислительного стресса в патогенезе хронического бактериального простатита (обзор литературы)Mechanisms of oxidative stress in the pathogenesis of chronic bacterial prostatitis (literature review)https://orcid.org/0000-0002-0906-9851БратчиковО. И.BratchikovO. I.

Олег Иванович Братчиков

305041 Курск, ул. Карла Маркса, 3

Oleg Ivanovich Bratchikov

3 Karla Marksa St., Kursk 305041

bratov45@mail.ruhttps://orcid.org/0000-0001-9265-9467ДубоносП. А.DubonosP. A.

305041 Курск, ул. Карла Маркса, 3

3 Karla Marksa St., Kursk 305041

https://orcid.org/0000-0001-6316-9020ТюзиковИ. А.TyuzikovI. A.

Ярославль 150000, Первомайский пер., 3в

3v Pervomayskiy Ln., Yaroslavl 150000

https://orcid.org/0000-0003-2233-256XШумаковаЕ. А.SchumakovaE. A.

305041 Курск, ул. Карла Маркса, 3

3 Karla Marksa St., Kursk 305041

ФГБОУ ВО «Курский государственный медицинский университет»РоссияKursk State Medical UniversityRussian FederationМедицинский центр «Тандем-Плюс»РоссияMedical Center “Tandem-Plus”Russian Federation2022090920222331928Copyright © Братчиков О.И., Дубонос П.А., Тюзиков И.А., Шумакова Е.А., 20222022Братчиков О.И., Дубонос П.А., Тюзиков И.А., Шумакова Е.А.Bratchikov O.I., Dubonos P.A., Tyuzikov I.A., Schumakova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/581

В обзорной статье на основе результатов современных клинико-экспериментальных исследований рассматриваются общие вопросы патофизиологии окислительного стресса как универсального патогенетического фактора заболеваний человека, а также частные патофизиологические аспекты окислительного стресса на примере хронического бактериального простатита. Отдельно освещены наиболее изученные механизмы окислительного стресса в патогенезе инфекционно-воспалительного процесса, связанного с хроническим бактериальным простатитом, которые способствуют возникновению и персистенции оксидативных нарушений в предстательной железе и нарушают полноценное восстановление ее анатомо-функционального состояния после перенесенного воспаления с потенциально негативным влиянием на результаты стандартной фармакотерапии хронического бактериального простатита.

The review article, based on the results of modern clinical and experimental studies, discusses general issues of the pathophysiology of oxidative stress as a universal pathogenetic factor of human diseases and particular pathophysiological aspects of oxidative stress on the example of chronic bacterial prostatitis. Separately, the most studied mechanisms of oxidative stress in the pathogenesis of the infectious and inflammatory process associated with chronic bacterial prostatitis are highlighted, which contribute to the occurrence and persistence of oxidative disorders in the prostate gland and disrupt the full restoration of its anatomical and functional state after inflammation with a potentially negative effect on the results of standard chronic bacterial prostatitis pharmacotherapy.

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The authors declare that there are no conflicts of interest present.