agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/1726-9784-2021-22-4-13-21agx-517Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWФакторы риска развития эректильной дисфункции: известные и неожиданные факты (обзор литературы)Risk factors for erectile dysfunction: known and unexpected facts (review)https://orcid.org/0000-0002-9128-2714ГамидовС. И.GamidovS. I.

Отделение андрологии и урологии.

117198 Москва, ул. Академика Опарина, 4.

Department of Andrology and Urology.

4 Akademika Oparina St., Moscow 117198.

https://orcid.org/0000-0001-8219-5216ОвчинниковР. И.OvchinnikovR. I.

Овчинников Руслан Игоревич - отделение андрологии и урологии.

117198 Москва, ул. Академика Опарина, 4.

Ruslan I. Ovchinnikov - Department of Andrology and Urology.

4 Akademika Oparina St., Moscow 117198.

riododc@rambler.ruhttps://orcid.org/0000-0003-1163-5602ПоповаА. Ю.PopovaA. Yu.

Отделение андрологии и урологии.

117198 Москва, ул. Академика Опарина, 4.

Department of Andrology and Urology.

4 Akademika Oparina St., Moscow 117198.

https://orcid.org/0000-0002-3902-9236ШатылкоТ. В.ShatylkoT. V.

Отделение андрологии и урологии.

117198 Москва, ул. Академика Опарина, 4.

Department of Andrology and Urology.

4 Akademika Oparina St., Moscow 117198.

Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В. И. Кулакова Минздрава РоссииРоссияV. I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of RussiaRussian Federation2021161220212241321Copyright © Гамидов С.И., Овчинников Р.И., Попова А.Ю., Шатылко Т.В., 20212021Гамидов С.И., Овчинников Р.И., Попова А.Ю., Шатылко Т.В.Gamidov S.I., Ovchinnikov R.I., Popova A.Y., Shatylko T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/517

Распространенность эректильной дисфункции (ЭД) среди мужчин старше 50 лет составляет 31-51 %. Ожидается, что к 2025 г. число пациентов с ЭД во всем мире увеличится до 322 млн. В России, по данным академика Д.Ю. Пушкаря, ЭД страдает до 89,9 % мужчин.

В связи с этим представляется весьма важным установление причин возникновения данного состояния. Целью настоящего обзора является представление современных данных литературы по вопросу, касающемуся факторов риска, приводящих к ЭД или ассоциированных с развитием ЭД.

Представленные работы показывают, что в возникновении ЭД играют роль хорошо известные факторы: неблагоприятное состояние окружающей среды, вредные факторы образа жизни, хроническая интоксикация, ожирение, генетическая предрасположенность, дефицит половых гормонов и витаминов, заболевания сердечно-сосудистой системы, предстательной железы и уретры, а также препараты для их лечения. В обзоре также рассмотрены новые показатели лабораторных и инструментальных исследований, изменяющиеся при ЭД.

Помимо работ, посвященных известным факторам риска, встречаются оригинальные работы, содержащие весьма неожиданные факты.

В настоящее время изучается взаимосвязь ЭД с репродуктивными нарушениями, псориазом, периодонтитом, инфицированностью вирусом иммунодефицита человека и приемом нестероидных противовоспалительных средств, что представлено в настоящем обзоре.

The prevalence of erectile dysfunction (ED) among men over 50 years is 31-51 %. By 2025, the prevalence of ED is expected to increase to 322 million men worldwide. In Russia, according to academician D.Yu. Pushkar', ED suffers up to 89.9 %.

In this regard, it seems very important to establish the causes of this condition. The purpose of this review is to assess the current state of the literature on the issue of risk factors leading to or associated with the development of ED.

The presented works show that well-known factors play a role in the occurrence of ED: unfavorable environmental conditions, harmful lifestyle factors, chronic intoxication, obesity, genetic predisposition, deficiency of sex hormones and vitamins, diseases of the cardiovascular system, prostate and urethra, as well as drugs for their treatment. Also, new indicators in laboratory and instrumental studies that change with ED are considered.

Among the well-known data, there are also some very original works devoted to this topic. The relationship between ED and reproductive disorders, psoriasis, periodontitis, human immunodeficiency virus infection and some drugs use is now being investigated, which is presented in this review.

эректильная дисфункцияфакторы рискаметаанализобзор литературыerectile dysfunctionrisk factorsmeta-analysisliterature reviewReferencesJohannes C.B., Araujo A.B., Feldman H.A. et al. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol 2000;163(2):460-3. DOI: 10.1016/s0022-5347(05)67903-7.Johannes C.B., Araujo A.B., Feldman H.A. et al. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol 2000;163(2):460-3. DOI: 10.1016/s0022-5347(05)67903-7.Laumann E.O., Paik A., Rosen R.C. et al. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281(6):537-44. DOI: 10.1001/jama.281.6.537.Laumann E.O., Paik A., Rosen R.C. et al. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999;281(6):537-44. DOI: 10.1001/jama.281.6.537.Selvin E., Burnett A.L., Platz E.A. et al. Prevalence and risk factors for erectile dysfunction in the US. Am J Med 2007;120(2):151-7. DOI: 10.1016/j.amjmed.2006.06.010.Selvin E., Burnett A.L., Platz E.A. et al. Prevalence and risk factors for erectile dysfunction in the US. Am J Med 2007;120(2):151-7. DOI: 10.1016/j.amjmed.2006.06.010.Ayta I.A., McKinlay J.B., Krane R.J. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84(1):50-6. DOI: 10.1046/j.1464-410x.1999.00142.x.Ayta I.A., McKinlay J.B., Krane R.J. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84(1):50-6. DOI: 10.1046/j.1464-410x.1999.00142.x.Rosen R.C., Fisher W.A., Eardley I. et al. The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 2004;20(5):607-17. DOI: 10.1185/030079904125003467.Rosen R.C., Fisher W.A., Eardley I. et al. The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 2004;20(5):607-17. DOI: 10.1185/030079904125003467.Пушкарь Д.Ю., Камалов А.А., Аль-Шукри С.Х. и др. Анализ результатов эпидемиологического исследования распространенности эректильной дисфункции в Российской Федерации. Урология 2012;6:5-9.Pushkar' D.Yu., Kamalov A.A., Al-Shukri S.H. et al. Analysis of the results of an epidemiological study of the prevalence of erectile dysfunction in the Russian Federation. Urologiya = Urology 2012;6:5-9. (In Russ.).Wang X.M., Bai Y.J., Yang Y.B. et al. Alcohol intake and risk of erectile dysfunction: a dose-response metaanalysis of observational studies. Int J Impot Res 2018;30(6):342-51. DOI: 10.1038/s41443-018-0022-x.Wang X.M., Bai Y.J., Yang Y.B. et al. Alcohol intake and risk of erectile dysfunction: a dose-response metaanalysis of observational studies. Int J Impot Res 2018;30(6):342-51. DOI: 10.1038/s41443-018-0022-x.Pizzol D., Demurtas J., Stubbs B. et al. Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis. Am J Mens Health 2019;13(6):1557988319892464. DOI: 10.1177/1557988319892464.Pizzol D., Demurtas J., Stubbs B. et al. Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis. Am J Mens Health 2019;13(6):1557988319892464. DOI: 10.1177/1557988319892464.Zhao S., Deng T., Luo L. et al. Association Between Opioid Use and Risk of Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2017;14(10):1209-19. DOI: 10.1016/j.jsxm.2017.08.010.Zhao S., Deng T., Luo L. et al. Association Between Opioid Use and Risk of Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2017;14(10):1209-19. DOI: 10.1016/j.jsxm.2017.08.010.Ismail S.B., Noor N.M., Hussain N.H.N. et al. Angiotensin Receptor Blockers for Erectile Dysfunction in Hypertensive Men: A Brief Meta-Analysis of Randomized Control Trials. Am J Mens Health 2019;13(6):1557988319892735. DOI: 10.1177/1557988319892735.Ismail S.B., Noor N.M., Hussain N.H.N. et al. Angiotensin Receptor Blockers for Erectile Dysfunction in Hypertensive Men: A Brief Meta-Analysis of Randomized Control Trials. Am J Mens Health 2019;13(6):1557988319892735. DOI: 10.1177/1557988319892735.Akdemir A.O., Karabakan M., Aktas B.K. et al. Visceral adiposity index is useful for evaluating obesity effect on erectile dysfunction. Andrologia 2019;51(6):e13282. DOI: 10.1111/and.13282.Akdemir A.O., Karabakan M., Aktas B.K. et al. Visceral adiposity index is useful for evaluating obesity effect on erectile dysfunction. Andrologia 2019;51(6):e13282. DOI: 10.1111/and.13282.Bohm M., Baumhakel M., Teo K. et al. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials. Circulation 2010;121(12):1439-46. DOI: 10.1161/CIRCULATIONAHA. 109.864199.Bohm M., Baumhakel M., Teo K. et al. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials. Circulation 2010;121(12):1439-46. DOI: 10.1161/CIRCULATIONAHA. 109.864199.Dong J.Y., Zhang Y.H., Qin L.Q. Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies. J Am Coll Cardiol 2011;58(13):1378 -85. DOI: 10.1016/j.jacc.2011.06.024.Dong J.Y., Zhang Y.H., Qin L.Q. Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies. J Am Coll Cardiol 2011;58(13):1378 -85. DOI: 10.1016/j.jacc.2011.06.024.Schouten B.W., Bohnen A.M., Bosch J.L. et al. Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: results from the Krimpen Study. Int J Impot Res 2008;20(1):92-9. DOI: 10.1038/sj.ijir.3901604.Schouten B.W., Bohnen A.M., Bosch J.L. et al. Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: results from the Krimpen Study. Int J Impot Res 2008;20(1):92-9. DOI: 10.1038/sj.ijir.3901604.Nehra A., Jackson G., Miner M. et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc 2012;87(8):766-78. DOI: 10.1016/j.mayocp.2012.06.015.Nehra A., Jackson G., Miner M. et al. The Princeton III Consensus recommendations for the management of erectile dysfunction and cardiovascular disease. Mayo Clin Proc 2012;87(8):766-78. DOI: 10.1016/j.mayocp.2012.06.015.Batty G.D., Li Q., Czernichow S. et al. Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial. J Am Coll Cardiol 2010;56(23):1908-13. DOI: 10.1016/j.jacc.2010.04.067.Batty G.D., Li Q., Czernichow S. et al. Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: prospective cohort study based on the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation) trial. J Am Coll Cardiol 2010;56(23):1908-13. DOI: 10.1016/j.jacc.2010.04.067.Ning L., Yang L. Hypertension might be a risk factor for erectile dysfunction: a meta-analysis. Andrologia 2017;49(4). DOI: 10.1111/and.12644.Ning L., Yang L. Hypertension might be a risk factor for erectile dysfunction: a meta-analysis. Andrologia 2017;49(4). DOI: 10.1111/and.12644.Osondu C.U., Vo B., Oni E.T. et al. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vasc Med 2018;23(1):9-20. DOI: 10.1177/1358863X17725809.Osondu C.U., Vo B., Oni E.T. et al. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vasc Med 2018;23(1):9-20. DOI: 10.1177/1358863X17725809.Chokesuwattanaskul R., Thongprayoon C., Pachariyanon P. et al. Erectile dysfunction and atrial fibrillation: A systematic review and meta-analysis. Int J Urol 2018;25(8):752-7. DOI: 10.1111/iju.13725.Chokesuwattanaskul R., Thongprayoon C., Pachariyanon P. et al. Erectile dysfunction and atrial fibrillation: A systematic review and meta-analysis. Int J Urol 2018;25(8):752-7. DOI: 10.1111/iju.13725.Fan Y., Hu B., Man C. et al. Erectile dysfunction and risk of cardiovascular and all-cause mortality in the general population: a meta-analysis of cohort studies. World J Urol 2018;36(10):1681-9. DOI: 10.1007/s00345-018-2318-3.Fan Y., Hu B., Man C. et al. Erectile dysfunction and risk of cardiovascular and all-cause mortality in the general population: a meta-analysis of cohort studies. World J Urol 2018;36(10):1681-9. DOI: 10.1007/s00345-018-2318-3.Besiroglu H., Otunctemur A., Ozbek E.J. The relationship between metabolic syndrome, its components, and erectile dysfunction: a systematic review and a meta-analysis of observational studies. J Sex Med 2015;12(6):1309-18. DOI: 10.1111/jsm.12885.Besiroglu H., Otunctemur A., Ozbek E.J. The relationship between metabolic syndrome, its components, and erectile dysfunction: a systematic review and a meta-analysis of observational studies. J Sex Med 2015;12(6):1309-18. DOI: 10.1111/jsm.12885.Wang X., Yang X., Cai Y. et al. High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. J Sex Med 2018;15(7):935-41. DOI: 10.1016/j.jsxm.2018.05.007.Wang X., Yang X., Cai Y. et al. High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. J Sex Med 2018;15(7):935-41. DOI: 10.1016/j.jsxm.2018.05.007.Liu Q., Zhang Y., Wang J. et al. Erectile Dysfunction and Depression: A Systematic Review and Meta-Analysis. J Sex Med 2018;15(8):1073-82. DOI: 10.1016/j.jsxm.2018.05.016.Liu Q., Zhang Y., Wang J. et al. Erectile Dysfunction and Depression: A Systematic Review and Meta-Analysis. J Sex Med 2018;15(8):1073-82. DOI: 10.1016/j.jsxm.2018.05.016.Kellesarian S.V., Malignaggi V.R., Feng C. et al. Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis. Int J Impot Res 2018;30(3):129-140. DOI: 10.1038/s41443-018-0017-7.Kellesarian S.V., Malignaggi V.R., Feng C. et al. Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis. Int J Impot Res 2018;30(3):129-140. DOI: 10.1038/s41443-018-0017-7.Ye T., Li J., Li L. et al. Computed tomography cavernosography combined with volume rendering to observe venous leakage in young patients with erectile dysfunction. Br J Radiol 2018;91(1091):20180118. DOI: 10.1259/bjr.20180118.Ye T., Li J., Li L. et al. Computed tomography cavernosography combined with volume rendering to observe venous leakage in young patients with erectile dysfunction. Br J Radiol 2018;91(1091):20180118. DOI: 10.1259/bjr.20180118.Kostis J.B., Dobrzynski J.M. The effect of statins on erectile dysfunction: a metaanalysis of randomized trials. J Sex Med 2014;11(7):1626-35. DOI: 10.1111/jsm.12521.Kostis J.B., Dobrzynski J.M. The effect of statins on erectile dysfunction: a metaanalysis of randomized trials. J Sex Med 2014;11(7):1626-35. DOI: 10.1111/jsm.12521.Elgendy A.Y., Elgendy I.Y., Mahmoud A.N. et al. Statin Use in Men and New Onset of Erectile Dysfunction: A Systematic Review and Meta-Analysis. Am J Med 2018;131(4):387-94. DOI: 10.1016/j.amjmed.2017.10.043.Elgendy A.Y., Elgendy I.Y., Mahmoud A.N. et al. Statin Use in Men and New Onset of Erectile Dysfunction: A Systematic Review and Meta-Analysis. Am J Med 2018;131(4):387-94. DOI: 10.1016/j.amjmed.2017.10.043.Liu C., Lu K., Tao T. et al. Endothelial nitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis. J Sex Med 2015;12(6):1319-28. DOI: 10.1111/jsm.12896.Liu C., Lu K., Tao T. et al. Endothelial nitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis. J Sex Med 2015;12(6):1319-28. DOI: 10.1111/jsm.12896.Yao H.X., Ma F.Z., Tan Y.Y. et al. Endothelial nitric oxide synthase gene polymorphisms and risk of erectile dysfunction: An updated meta-analysis of genetic association studies. Int J Surg 2018;54(Pt A):141-8. DOI: 10.1016/j.ijsu.2018.04.012.Yao H.X., Ma F.Z., Tan Y.Y. et al. Endothelial nitric oxide synthase gene polymorphisms and risk of erectile dysfunction: An updated meta-analysis of genetic association studies. Int J Surg 2018;54(Pt A):141-8. DOI: 10.1016/j.ijsu.2018.04.012.Zhang T., Li W.L., He X.F. et al. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene and erectile dysfunction risk: a meta-analysis. Andrology 2013;1(2):274-80. DOI: 10.1111/j.2047-2927.2012.00029.x.Zhang T., Li W.L., He X.F. et al. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene and erectile dysfunction risk: a meta-analysis. Andrology 2013;1(2):274-80. DOI: 10.1111/j.2047-2927.2012.00029.x.Mulhall J.P., Trost L.W., Brannigan R.E. et al. Evaluation and Management of Testosterone Deficiency: AUA Guideline. J Urol 2018;200(2):423-32. DOI: 10.1016/j.juro.2018.03.115.Mulhall J.P., Trost L.W., Brannigan R.E. et al. Evaluation and Management of Testosterone Deficiency: AUA Guideline. J Urol 2018;200(2):423-32. DOI: 10.1016/j.juro.2018.03.115.Huang Y.P., Liu W., Chen S.F. et al. Free testosterone correlated with erectile dysfunction severity among young men with normal total testosterone. Int J Impot Res 2019;31(2):132-8. DOI: 10.1038/s41443-018-0090-y.Huang Y.P., Liu W., Chen S.F. et al. Free testosterone correlated with erectile dysfunction severity among young men with normal total testosterone. Int J Impot Res 2019;31(2):132-8. DOI: 10.1038/s41443-018-0090-y.Zuniga K.B., Margolin E.J., De Fazio A. et al. The association between elevated serum oestradiol levels and clinically significant erectile dysfunction in men presenting for andrological evaluation. Andrologia 2019;51(9):e13345. DOI: 10.1111/and.13345.Zuniga K.B., Margolin E.J., De Fazio A. et al. The association between elevated serum oestradiol levels and clinically significant erectile dysfunction in men presenting for andrological evaluation. Andrologia 2019;51(9):e13345. DOI: 10.1111/and.13345.Wei Y., Chen P., Chen Q. et al. Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis. Andrologia 2019;51(3):e13211. DOI: 10.1111/and.13211.Wei Y., Chen P., Chen Q. et al. Serum vitamin D levels and erectile dysfunction: A systematic review and meta-analysis. Andrologia 2019;51(3):e13211. DOI: 10.1111/and.13211.Li H.J., Kang D.Y. Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis. World J Urol 2016;34(7):1009-17. DOI: 10.1007/s00345-015-1720-3.Li H.J., Kang D.Y. Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: a meta-analysis. World J Urol 2016;34(7):1009-17. DOI: 10.1007/s00345-015-1720-3.Corona G., Tirabassi G., Santi D. et al. Sexual dysfunction in subjects treated with inhibitors of 5a-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis. Andrology 2017;5(4):671-8. DOI: 10.1111/andr.12353.Corona G., Tirabassi G., Santi D. et al. Sexual dysfunction in subjects treated with inhibitors of 5a-reductase for benign prostatic hyperplasia: a comprehensive review and meta-analysis. Andrology 2017;5(4):671-8. DOI: 10.1111/andr.12353.Favilla V., Russo G.I., Privitera S. et al. Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alphablockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/ BPH: a systematic review with metaanalysis. Aging Male 2016;19(3):175-81. DOI: 10.1080/13685538.2016.1195361.Favilla V., Russo G.I., Privitera S. et al. Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alphablockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/ BPH: a systematic review with metaanalysis. Aging Male 2016;19(3):175-81. DOI: 10.1080/13685538.2016.1195361.Kallidonis P., Russo G.I., Privitera S. et al. Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alpha-blockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/BPH: a systematic review with meta-analysis. Aging Male 2016;19(3):175-81. DOI: 10.1080/13685538.2016.1195361.Kallidonis P., Russo G.I., Privitera S. et al. Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alpha-blockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/BPH: a systematic review with meta-analysis. Aging Male 2016;19(3):175-81. DOI: 10.1080/13685538.2016.1195361.Vasudeva P., Kumar N., Kumar A. et al. Impact of monopolar TURP, bipolar TURP and photoselective vaporization of prostate for enlarged prostate on erectile function. Low Urin Tract Symptoms 2019;11(1):24-9. DOI: 10.1111/luts.12189.Vasudeva P., Kumar N., Kumar A. et al. Impact of monopolar TURP, bipolar TURP and photoselective vaporization of prostate for enlarged prostate on erectile function. Low Urin Tract Symptoms 2019;11(1):24-9. DOI: 10.1111/luts.12189.Gaither T.W., Awad M.A., Osterberg E.C. et al. The Natural History of Erectile Dysfunction After Prostatic Radiotherapy: A Systematic Review and Meta-Analysis. J Sex Med 2017;14(9):1071-8. DOI: 10.1016/j.jsxm.2017.07.010.Gaither T.W., Awad M.A., Osterberg E.C. et al. The Natural History of Erectile Dysfunction After Prostatic Radiotherapy: A Systematic Review and Meta-Analysis. J Sex Med 2017;14(9):1071-8. DOI: 10.1016/j.jsxm.2017.07.010.Zhou J.T., Fang D.M., Xia S. et al. The incidence proportion of erectile dysfunction in patients treated with cryotherapy for prostate cancer: a metaanalysis. Clin Transl Oncol 2019;21(9):1152-8. DOI: 10.1007/s12094-019-02036-8.Zhou J.T., Fang D.M., Xia S. et al. The incidence proportion of erectile dysfunction in patients treated with cryotherapy for prostate cancer: a metaanalysis. Clin Transl Oncol 2019;21(9):1152-8. DOI: 10.1007/s12094-019-02036-8.Blaschko S.D., Sanford M.T., Cinman N.M. et al. De novo erectile dysfunction after anterior urethroplasty: a systematic review and meta-analysis. BJU Int 2013;112(5):655-63. DOI: 10.1111/j.1464-410X.2012.11741.x.Blaschko S.D., Sanford M.T., Cinman N.M. et al. De novo erectile dysfunction after anterior urethroplasty: a systematic review and meta-analysis. BJU Int 2013;112(5):655-63. DOI: 10.1111/j.1464-410X.2012.11741.x.Lotti F., Maggi M. Sexual dysfunction and male infertility. Nat Rev Urol 2018;15(5):287-307. DOI: 10.1038/nrurol.2018.20.Lotti F., Maggi M. Sexual dysfunction and male infertility. Nat Rev Urol 2018;15(5):287-307. DOI: 10.1038/nrurol.2018.20.Kizilay F., §ahin M., Altay B. Do sperm parameters and infertility affect sexuality of couples? Andrologia 2018;50(2). DOI: 10.1111/and.12879.Kizilay F., §ahin M., Altay B. Do sperm parameters and infertility affect sexuality of couples? Andrologia 2018;50(2). DOI: 10.1111/and.12879.Coward R.M., Stetter C., Kunselman A. et al. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. J Urol 2019;202(2):379-84. DOI: 10.1097/JU.0000000000000205.Coward R.M., Stetter C., Kunselman A. et al. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. J Urol 2019;202(2):379-84. DOI: 10.1097/JU.0000000000000205.Corona G., Rastrelli G., Limoncin E. et al. Interplay Between Premature Ejaculation and Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2015;12(12):2291-300. DOI: 10.1111/jsm.13041.Corona G., Rastrelli G., Limoncin E. et al. Interplay Between Premature Ejaculation and Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2015;12(12):2291-300. DOI: 10.1111/jsm.13041.Liu L.H., Li E.M., Zhong S.L. et al. Chronic periodontitis and the risk of erectile dysfunction: a systematic review and meta-analysis. Int J Impot Res 2017;29(1): 43-8. DOI: 10.1038/ijir.2016.43.Liu L.H., Li E.M., Zhong S.L. et al. Chronic periodontitis and the risk of erectile dysfunction: a systematic review and meta-analysis. Int J Impot Res 2017;29(1): 43-8. DOI: 10.1038/ijir.2016.43.Zhang F.B., Wu B.C., Xie L.B. et al. [Correlation of psoriasis with erectile dysfunction: A meta-analysis. (In Chinese)]. Zhonghua Nan Ke Xue 2017;23(3):256-61.Zhang F.B., Wu B.C., Xie L.B. et al. [Correlation of psoriasis with erectile dysfunction: A meta-analysis. (In Chinese)]. Zhonghua Nan Ke Xue 2017;23(3):256-61.Wu T., Duan X., Chen S. et al. Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis. J Sex Med 2018;15(6):839-47. DOI: 10.1016/j.jsxm.2018.04.630.Wu T., Duan X., Chen S. et al. Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis. J Sex Med 2018;15(6):839-47. DOI: 10.1016/j.jsxm.2018.04.630.Zhao S., Wang J., Xie Q. et al. High prevalence of erectile dysfunction in men with psoriasis: evidence from a systematic review and meta-analysis. Int J Impot Res 2019;31(2):74-84. DOI: 10.1038/s41443-018-0093-8.Zhao S., Wang J., Xie Q. et al. High prevalence of erectile dysfunction in men with psoriasis: evidence from a systematic review and meta-analysis. Int J Impot Res 2019;31(2):74-84. DOI: 10.1038/s41443-018-0093-8.Luo L., Deng T., Zhao S. et al. Association Between HIV Infection and Prevalence of Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2017;14(9):1125-32. DOI: 10.1016/j.jsxm.2017.07.001.Luo L., Deng T., Zhao S. et al. Association Between HIV Infection and Prevalence of Erectile Dysfunction: A Systematic Review and Meta-Analysis. J Sex Med 2017;14(9):1125-32. DOI: 10.1016/j.jsxm.2017.07.001.Li T., Wu C., Fu F. et al. Association between use of aspirin or nonaspirin non-steroidal anti-inflammatory drugs and erectile dysfunction: A systematic review. Medicine (Baltimore) 2018;97(28):e11367. DOI: 10.1097/MD.0000000000011367.Li T., Wu C., Fu F. et al. Association between use of aspirin or nonaspirin non-steroidal anti-inflammatory drugs and erectile dysfunction: A systematic review. Medicine (Baltimore) 2018;97(28):e11367. DOI: 10.1097/MD.0000000000011367.Aslan A., Kaya Y., Cirakoglu A. et al. Neutrophil-Lymphocyte Ratio Could Be a Marker for Erectile Dysfunction. Urol J 2019;16(2):216-20. DOI: 10.22037/uj.v16i2.5011.Aslan A., Kaya Y., Cirakoglu A. et al. Neutrophil-Lymphocyte Ratio Could Be a Marker for Erectile Dysfunction. Urol J 2019;16(2):216-20. DOI: 10.22037/uj.v16i2.5011.Ren Z.J., Ren P.W., Yang B. et al. Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis. Andrologia 2017;49(10). DOI: 10.1111/and.12777.Ren Z.J., Ren P.W., Yang B. et al. Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis. Andrologia 2017;49(10). DOI: 10.1111/and.12777.Yang G., Muzepper M. Platelet indices and erectile dysfunction: A systematic review and meta-analysis. Andrologia 2019;51(5):e13248. DOI: 10.1111/and.13248.Yang G., Muzepper M. Platelet indices and erectile dysfunction: A systematic review and meta-analysis. Andrologia 2019;51(5):e13248. DOI: 10.1111/and.13248.Sansone A., Cignarelli A., Sansone M. et al. Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis. Int J Endocrinol 2018;2018:7424792. DOI: 10.1155/2018/7424792.Sansone A., Cignarelli A., Sansone M. et al. Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis. Int J Endocrinol 2018;2018:7424792. DOI: 10.1155/2018/7424792.

The authors declare that there are no conflicts of interest present.