agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/1726-9784-2021-22-3-11-17agx-500Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWВлияние тестостерона на пуриновый обмен и подагруInfluence of testosterone on purine metabolism and gouthttps://orcid.org/0000-0002-5290-156XПаневинТ. С.PanevinT. S.

Тарас Сергеевич Паневин

115522 Москва, Каширское шоссе, 34А119019 Москва, пер. Колымажный, 7, стр. 4

Taras Sergeevich Panevin

34A Kashirskoe Shosse, Moscow 115522Bld. 4, 7 Kolimazhniy per., Moscow 119019

tarasel@list.ruФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГКУ «Консультативно-диагностический центр Генерального штаба Вооруженных сил Российской Федерации»РоссияV.A. Nasonova Research Institute of Rheumatology; Consultative and Diagnostic center of the General Staff of the Armed Forces of the Russian FederationRussian Federation2021110920212231117Copyright © Паневин Т.С., 20212021Паневин Т.С.Panevin T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/500

В регуляции пуринового обмена участвует множество различных факторов. Немаловажную роль играет уровень половых гормонов: высокие концентрации андрогенов приводят к более высокому, а эстрогенов – к относительно низкому уровню мочевой кислоты. Однако, по результатам многочисленных исследований, показано, что влияние половых гормонов не ограничивается только концентрацией мочевой кислоты. Половые гормоны оказывают влияние на воспалительные процессы в организме, модулируя выработку провоспалительных цитокинов и регулируя соответствующие сигнальные пути. Дефицит андрогенов может приводить к развитию ожирения и метаболических нарушений, что может вносить вклад в развитие и течение подагры. В данном обзоре рассмотрено влияние тестостерона, а также изменений его концентрации на динамику пуринового обмена и подагру.

Many different factors are involved in the regulation of purine metabolism. An important role is played by the level of sex hormones: high concentrations of androgens lead to a higher, and estrogen – to a lower level of uric acid. However, according to the results of numerous studies, it has been shown that the effect of sex hormones is not limited only to the uric acid concentration. Sex hormones affect inflammatory processes in the body by modulating the production of pro-inflammatory cytokines and regulating the corresponding signaling pathways. Androgen deficiency can lead to obesity and metabolic disorders, which can contribute to the development and course of gout. This review examines the effect of testosterone, as well as the effect of changes in its concentration on the dynamics of purine metabolism and gout.

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The authors declare that there are no conflicts of interest present.