agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-8902MedINK Publishing House LLC10.17650/2070-9781-2020-21-4-40-46agx-456Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWВоздействие антибактериальных препаратов на сперматогенез (обзор литературы)The effect of antibiotics on spermatogenesis (review)https://orcid.org/0000-0002-1108-8138КадыровЗ. А.KadyrovZ. A.

Зиератшо Абдуллоевич Кадыров

117198 Москва, ул. Миклухо-Маклая, 6

zieratsho@yandex.ruАкрамовМ. М.AkramovM. M.АлдыраковЭ. М.AldyrakovE. M.ФГАОУ ВО «Российский университет дружбы народов»РоссияRUDN UniversityRussian Federation2020120220212144046Copyright © Кадыров З.А., Акрамов М.М., Алдыраков Э.М., 20212021Кадыров З.А., Акрамов М.М., Алдыраков Э.М.Kadyrov Z.A., Akramov M.M., Aldyrakov E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/456

В обзоре проанализированы последние данные о воздействии антибиотиков на состояние и функцию репродуктивных органов. Во многих экспериментальных исследованиях продемонстрировано отрицательное влияние некоторых антибиотиков на сперматогенез, которое зависит от дозы. В отличие от лекарственных препаратов других групп, цитотоксическое действие которых на ткань яичка может быть прямым или опосредованным (через изменение уровня гормонов гипоталамо-гипофизарногонадной оси), при использовании некоторых антибиотиков чаще всего на фоне воспалительного процесса развивается окислительный стресс в тканях яичек, что приводит к дистрофическим изменениям и ухудшению сперматогенеза.

This review analyzes studies on the negative effects of antibiotics on reproductive organs and their function. Many experimental studies record the negative effect of certain antibiotics, depending on the dose applied, on spermatogenesis. Unlike drugs of other groups, in which a direct cytotoxic effect on the testicular tissue occurs through a change in the level of hormones of the hypothalamic-pituitary-gonadal axis or through a direct effect on the testicle itself, when using some antibiotics, most often against the background of the inflammatory process, oxidative stress occurs in the testicular tissues, which leads to dystrophic lesions and violations of spermatogenesis indicators.

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The authors declare that there are no conflicts of interest present.