agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2020-21-4-20-30agx-454Research ArticleОБЗОРНАЯ СТАТЬЯREVIEWВирусное инфицирование сперматозоидов. Часть 2. Герпесвирусы человека, вирус иммунодефицита человека, вирус гепатита С, вирус Зика (обзор литературы)Viral infection of sperm. Part 2. Human herpes viruses, human immunodeficiency virus, hepatitis C virus, Zika virus (review)https://orcid.org/0000-0002-8422-4962БрагинаЕ. Е.BraginaE. E.

Елизавета Ефимовна Брагина

119992 Москва, Ленинские горы, 1, стр. 40

115522 Москва, ул. Москворечье, 1

Bld. 40, 1 Leninskie Gory, Moscow 119992

1 Moskvorechye St., Moscow 115522

bragor@mail.ruНаучно-исследовательский институт физико-химической биологии им. А. Н. Белозерского ФГБОУ ВО «Московский государственный университет им. М. В. Ломоносова»; ФГБНУ «Медико-генетический научный центр им. Н. П. Бочкова»РоссияA. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; N. P. Bochkov Research Centre for Medical GeneticsRussian Federation2020120220212142030Copyright © Брагина Е.Е., 20212021Брагина Е.Е.Bragina E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/454

Интрагаметное вирусное инфицирование сперматозоидов может быть причиной истинной вертикальной передачи вирусов через половые клетки. В сперматозоидах обнаружены вирус иммунодефицита человека, вирус гепатита С, вирус простого герпеса, цитомегаловирус, вирус Зика. Доказана возможность вертикальной передачи вируса иммунодефицита человека, вируса простого герпеса, вируса Зика.

Интрагаметное инфицирование сперматозоидов герпесвирусами приводит к аномалиям развития эмбриона и может являться причиной спонтанных абортов как при естественном зачатии, так и при применении вспомогательных репродуктивных технологий.

Разработка методов диагностики интрагаметного вирусного инфицирования сперматозоидов позволит в некоторых случаях установить причину бесплодия и аномалий беременности и применить соответствующую антивирусную терапию на стадии подготовки к естественному зачатию или применению вспомогательных репродуктивных технологий.

Intragametal viral infection of spermatozoa can cause true vertical transmission of viruses through germ cells. Currently, human immunodeficiency virus, hepatitis C viruses, herpes simplex virus, cytomegalovirus, Zika virus have been detected in spermatozoa. The possibility of vertical transmission of human immunodeficiency virus, cytomegalovirus, herpes simplex virus and Zika virus has been proven.

Intragametal infection of spermatozoa with viruses of the herpes group leads to abnormalities in the development of the embryo and can cause spontaneous abortions both during natural conception and when using assisted reproductive technologies.

The development of adequate methods for diagnosing an intragametal spermatozoa virus infection will make it possible to find out, at least in some patients, the cause of infertility and pregnancy abnormalities and apply appropriate antiviral therapy in preparation for natural conception or the use of assisted reproductive technologies.

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The authors declare that there are no conflicts of interest present.