References

agx

Андрология и генитальная хирургия

Andrology and Genital Surgery

2070-97812412-8902

10.17650/2070-9781-2020-21-1-14-21

agx-394

Research Article

ОБЗОРНАЯ СТАТЬЯ

REVIEW

Индекс фрагментации ДНК сперматозоидов – необходимость для современной клинической практики

Sperm DNA fragmentation is a necessity for modern clinical practice

https://orcid.org/0000-0002-9041-2687

Епанчинцева

Е. А.

Epanchintseva

E. A.

Елена Александровна Епанчинцева

EpanE@yandex.ru

https://orcid.org/0000-0003-4534-7289

Селятицкая

В. Г.

Selyatitskaya

V. G.

https://orcid.org/0000-0003-2750-0382

Божедомов

В. А.

Bozhedomov

V. A.

ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»; ООО «Новосибирский центр репродуктивной медицины» ГК «Мать и дитя»РоссияFederal Research Center of Fundamental and Translational Medicine; Novosibirsk Center for Reproductive Medicine, GС “Mother and Child”Russian Federation

ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»РоссияFederal Research Center of Fundamental and Translational MedicineRussian Federation

ФГБОУ «Московский государственный университет им. М.В. Ломоносова»РоссияLomonosov Moscow State UniversityRussian Federation

2020

02042020

2111421

2020

Епанчинцева Е.А., Селятицкая В.Г., Божедомов В.А.

Epanchintseva E.A., Selyatitskaya V.G., Bozhedomov V.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://agx.elpub.ru/jour/article/view/394

По мировой статистике у 15 % супружеских пар, стремящихся зачать ребенка, беременность не наступает в течение 1 года, после чего они обращаются за медицинской помощью. При этом проблема бесплодия считается комплексной, так как, помимо ненаступления беременности, важной ее составляющей является невынашивание беременности. По современным представлениям, одна из причин прерывания беременности – повышенный уровень фрагментации ДНК сперматозоидов (ФДС). В руководстве по диагностике и лечению мужского бесплодия Европейской ассоциации урологов указано, что ФДС снижает шансы на зачатие естественным путем и повышает риск невынашивания беременности. В руководстве по лечению привычного невынашивания беременности, разработанном Европейским обществом специалистов по репродукции и эмбриологии человека, рекомендовано определять индекс ФДС в ходе обследования пары после 1 эпизода самопроизвольного прерывания беременности. Причины и механизмы повышения уровня ФДС, а также подходы к его коррекции – предмет активного изучения: в настоящий момент в PubMed содержится более 2500 работ по этой проблеме. Ввиду огромного количества источников целью настоящего обзора стало освещение ключевых вопросов – этиологии, патогенеза и подходов к коррекции повышенного уровня ФДС.

Авторы заявляют об отсутствии конфликта интересов.

According to world statistics, 15 % of married couples do not reach pregnancy within one year and seek medical help. At the same time, an important component of the complex problem of infertility, in addition to not getting pregnant, are also pregnancy losses. According to modern ideas, one of the reasons for termination of pregnancy is sperm DNA fragmentation (SDF). According to the European Association of Urology guidelines on male infertility, SDF reduces the chances of natural conception and increases the risk of pregnancy loss. In the European Society of Human Reproduction and Embryology guideline on the management of recurrent pregnancy loss, the definition of SDF is recommended in the algorithm for examining a couple after a single episode of miscarriage. The causes, mechanisms and approaches to correcting increased SDF are the subject of active research; according to PubMed, more than 2,500 papers have been published on this problem to date. Given the huge amount of factual material, the purpose of this review is to highlight the key points of etiology, pathogenesis and approaches to the correction of increased levels of SDF

фрагментация ДНК сперматозоидовиндекс фрагментации ДНК сперматозоидовэтиологияпатогенезлечениевыкидышраннее невынашивание беременностимужское бесплодие

sperm DNA fragmentationindex of sperm DNA fragmentationetiologypathogenesistreatmentmiscarriageearly pregnancy lossmale infertility

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The authors declare that there are no conflicts of interest present.