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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">agx</journal-id><journal-title-group><journal-title xml:lang="ru">Андрология и генитальная хирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Andrology and Genital Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2070-9781</issn><issn pub-type="epub">2412-8902</issn><publisher><publisher-name></publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17650/2070-9781-2018-19-4-60-66</article-id><article-id custom-type="elpub" pub-id-type="custom">agx-322</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORT</subject></subj-group></article-categories><title-group><article-title>Связь микробиоты уретры с качеством эякулята и содержанием эндокринных дисрапторов в семенной жидкости у мужчин</article-title><trans-title-group xml:lang="en"><trans-title>Connection of urethral microbiota with the semen quality and the concentration of endocrine disrupters in men semen</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7072-8289</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чигринец</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chigrinets</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Станислав Владимирович Чигринец.</p><p>454092 Челябинск, ул. Воровского, 64; 454048 Челябинск, ул. Яблочкина, 3</p></bio><bio xml:lang="en"><p>64 Vorovskogo St., Chelyabinsk 454092; 3 Yablochkina St., Chelyabinsk 454048</p></bio><email xlink:type="simple">chigrinstas@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3898-766X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брюхин</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bryuhin</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>454092 Челябинск, ул. Воровского, 64</p></bio><bio xml:lang="en"><p>64 Vorovskogo St., Chelyabinsk 454092</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России; ДНКклиника, ООО</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University, Ministry of Health of Russia; DNKClinic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2018</year></pub-date><volume>19</volume><issue>4</issue><fpage>60</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чигринец С.В., Брюхин Г.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Чигринец С.В., Брюхин Г.В.</copyright-holder><copyright-holder xml:lang="en">Chigrinets S.V., Bryuhin G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://agx.elpub.ru/jour/article/view/322">https://agx.elpub.ru/jour/article/view/322</self-uri><abstract><p>Цель исследования — установить связь между наличием условно-патогенных микроорганизмов уретры и качеством эякулята, а также концентрацией убиквитарных эндокринных дисрапторов (бисфенола А и триклозана) в семенной жидкости.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен анализ 63 образцов семенной жидкости мужчин с нормо- и патозооспермией. Определяли концентрацию бисфенола А и триклозана в семенной жидкости методом газовой хроматографии с масс-спектрометрией. Качественный и количественный состав микробиоценоза уретры исследовали методом полимеразной цепной реакции в режиме реального времени с помощью тест-системы «Андрофлор». Результаты были подвергнуты статистической обработке с использованием U-критерия Манна-Уитни и корреляционного анализа. Различия считали статистически значимыми при р &lt;0,05.</p></sec><sec><title>Результаты</title><p>Результаты. В 100 % образцов эякулята был обнаружен бисфенол А. Триклозан был выявлен в 84,9 % образцов. Группы мужчин с нормо- и патозооспермией статистически значимо различались по концентрации бисфенола А (р &lt;0,001) и триклозана (р = 0,003) в семенной жидкости. В ходе исследования были установлены статистически значимые корреляционные связи между концентрацией бисфенола А в семенной жидкости и наличием Lactobacillus spp. (r = 0,501, р = 0,003), Corynebacterium spp. (r = 0,425, р = 0,015), Anaerococcus spp. (r = 0,371, р = 0,045), Eubacterium spp. (r = 0,357, р = 0,037), а также между концентрацией триклозана и наличием Staphylococcus spp. (r = 0,392, р = 0,026), Streptococcus spp. (r = -0,486, р = 0,005).</p></sec><sec><title>Заключение</title><p>Заключение. В данном исследовании установлена связь количественного и качественного состава микробиоты уретры с характеристиками эякулята и содержанием эндокринных дисрапторов (бисфенола А и триклозана) в семенной жидкости у мужчин. В связи с этим необходимо учитывать роль бессимптомного дисбиоза уретры при введении пациентов с низким качеством эякулята.</p></sec></abstract><trans-abstract xml:lang="en"><p>The study objective is to investigate the correlations between opportunistic microorganisms of the urethra and the quality of ejaculate, as well as the concentration of ubiquitory endocrine disruptors (bisphenol A and triclosan) in men semen.</p><sec><title>Materials and methods</title><p>Materials and methods. We analysed 63 semen samples of men with normo- and patozoospermia. In seminal fluid the concentration of bisphenol A and triclosan was determined by gas chromatography with mass spectrometry. The microbiocenosis of the urethra was studied by real-time polymerase chain reaction using the Androflor test system. The results were subjected to statistical processing using the Mann — Whitney U-test and correlation analysis. A p-value less than 0.05 was considered significant.</p></sec><sec><title>Results</title><p>Results. Bisphenol A was found in 100 % of the semen samples. Triclosan was detected in 84.9 % of the samples. Comparison groups on the quality of ejaculate (normo- and pathozoospermia) were statistically significantly different in the concentration of bisphenol A and triclosan in seminal fluid (p &lt;0.001) and (p = 0.003) respectively. The study established statistically significant correlations between bisphenol A concentration, seminal triclosan and urethral microbiota: Lactobacillus spp. (r = 0.501, p = 0.003), Corynebacterium spp. (r = 0.425, p = 0.015), Anaerococcus spp. (r = 0.371, p = 0.045), Eubacterium spp. (r = 0.357, p = 0.037) for bisphenol A and Staphylococrns spp. (r = 0.392, p = 0.026), Streptococcus spp. (r = —0.486, p = 0.005) for triclosan.</p></sec><sec><title>Conclusion</title><p>Conclusion. In this study the connection of the urethral microbiota with the quality of the ejaculate and the concentration of endocrine dis-ruptors (bisphenol A and triclosan) in men semen was established. In this regard, it is necessary to take into account the role of asymptomatic urethral dysbiosis when administering patients with poor ejaculate quality.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>бесплодие</kwd><kwd>качество эякулята</kwd><kwd>эндокринный дисраптор</kwd><kwd>бисфенол А</kwd><kwd>триклозан</kwd><kwd>микробиота</kwd><kwd>дисбиоз</kwd><kwd>«Андрофлор»</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infertility</kwd><kwd>sperm quality</kwd><kwd>endocrine disruptor</kwd><kwd>bisphenolA</kwd><kwd>triclosan</kwd><kwd>microbiota</kwd><kwd>dysbiosis</kwd><kwd>Androflor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Andrology: male reproductive health and dysfunction. Ed. by E. Nieschlag, H.M. Behre, Nieschlag S. 3rd edn. 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