References

agx

Андрология и генитальная хирургия

Andrology and Genital Surgery

2070-97812412-8902

10.17650/2070-9781-2018-19-4-21-27

agx-317

Research Article

ОБЗОРНАЯ СТАТЬЯ

REVIEW

Докозагексаеновая кислота в лечении мужского бесплодия

Docosahexaenoic acid in the treatment of male infertility

https://orcid.org/0000-0001-7469-3952

Виноградов

И. В.

Vinogradov

I. V.

Игорь Владимирович Виноградов

117198 Москва, ул. Миклухо-Маклая, 6

6 Miklukho-Maklaya St., Moscow 117198

ivvinogradov@mail.ru

https://orcid.org/0000-0002-1651-4343

Живулько

А. Р.

Zhivulko

A. R.

117198 Москва, ул. Миклухо-Маклая, 6

6 Miklukho-Maklaya St., Moscow 117198

Виноградова

Л. М.

Vinogradova

L. M.

117198 Москва, ул. Миклухо-Маклая, 6

6 Miklukho-Maklaya St., Moscow 117198

Королев

С. В.

Korolev

S. V.

117198 Москва, ул. Миклухо-Маклая, 6

6 Miklukho-Maklaya St., Moscow 117198

ФГАОУ ВО Российский университет дружбы народовРоссияRUDN UniversityRussian Federation

2018

22122018

1942127

2018

Виноградов И.В., Живулько А.Р., Виноградова Л.М., Королев С.В.

Vinogradov I.V., Zhivulko A.R., Vinogradova L.M., Korolev S.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://agx.elpub.ru/jour/article/view/317

Обзор литературы посвящен анализу современных сведений о применении докозагексаеновой кислоты при лечении мужского бесплодия. Дано краткое описание современных представлений о возможных причинах мужского бесплодия — нарушении функции клеточной мембраны и повреждении генетического материала сперматозоидов. Подробно изложены данные о противовоспалительных свойствах омега-3-полиненасыщенных жирных кислот. Обсуждаются вопросы биодоступности докозагексаеновой кислоты и выбора содержащих ее препаратов для терапии мужского бесплодия. Повышение содержания полиненасыщенных жирных кислот, в частности докозагексаеновой кислоты, в мембране сперматозоидов было ассоциировано с более высокими показателями качества эякулята. Терапия с применением этих веществ приводила к улучшению стандартных показателей спермограммы и снижению доли сперматозоидов с фрагментированной ДНК.

Literature review is devoted to the analysis of modern data on the use of docosahexaenoic acid in the treatment of male infertility. A brief description of modern ideas about the possible causes of male infertility (a disturbance of function of the cell membrane and genetic damage of sperm) was conducted. The data on the anti-inflammatory properties of omega-3 polyunsaturated fatty acids are described in detail. The bioavailability of docosahexaenoic acid and the choice of drugs containing it for the treatment of male infertility are discussed. Increasing the content of polyunsaturated fatty acids, in particular docosahexaenoic acid, in the sperm membrane was associated with higher ejaculate quality. Therapy with the use of these substances led to the improvement of standard indicators of semen and a decrease in the proportion of sperm with fragmented DNA.

омега-3-полиненасыщенные жирные кислотыдокозагексаеновая кислотамужское бесплодиефрагментация ДНК сперматозоидов

omega-3 polyunsaturated fatty acidsdocosahexaenoic acidmale infertilitysperm DNA fragmentation

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The authors declare that there are no conflicts of interest present.