agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-8902MedINK Publishing House LLC10.17650/2070-9781-2016-17-3-23-37agx-199Research ArticleОБЗОРНЫЕ СТАТЬИREVIEWРоль микроРНК в сперматогенезеRole of microRNAs in spermatogenesisРудневаС. А.RudnevaS. A.

Москва, 115478, ул. Москворечье, 1

1 Moskvorech’e St., Moscow, 115478

sveta_a_r@mail.ruХаченковаА. А.KhachenkovaA. A.

Москва, 115478, ул. Москворечье, 1

1 Moskvorech’e St., Moscow, 115478

ФГБНУ «Медико-генетический научный центр»РоссияResearch Centre for Medical GeneticsRussian Federation2016071120161732337Copyright © Руднева С.А., Хаченкова А.А., 20162016Руднева С.А., Хаченкова А.А.Rudneva S.A., Khachenkova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/199

Мужские половые клетки имеют сложный транскриптом. Помимо кодирующих белки матричных РНК в нем присутствует много некодирующих РНК, включая микроРНК. Известно, что микроРНК – важные регуляторы экспрессии генов. Они функционируют в основном посттранскрипционно, контролируя трансляцию их целевых мессенджеров – матричных РНК – и участвуя в каждом этапе дифференцировки мужских половых клеток. В данном обзоре продемонстрировано значение путей микроРНК для нормального сперматогенеза. Определена функциональная роль ряда микроРНК на различных этапах дифференцировки половых клеток. Рассмотрены микроРНК в сперматозоидах и семенной плазме человека в качестве потенциальных биомаркеров мужского бесплодия.

Male germ cells have a complex transcriptome. In addition to proteincoding messenger RNAs, many noncoding RNAs, including microRNAs (miRNAs), are produced. The miRNAs are important regulators of gene expression. They function mainly post-transcriptionally to control the stability or translation of their target messenger RNAs. The miRNAs are expressed in a cell-specific manner during spermatogenesis to participate in the control of each stage of male germ cell differentiation. Clinical studies have exploited the well-defined expression profiles of miRNAs, and human spermatozoal or seminal plasma miRNAs have been explored as potential biomarkers for male factor infertility.

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The authors declare that there are no conflicts of interest present.