agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-8902MedINK Publishing House LLC10.17650/2070-9781-2015-16-2-51-55agx-146Research ArticleДИСКУССИЯОпыт применения докозагексаеновой кислоты (БрудиПлюс) у пациентов с повышенным индексом фрагментации ДНК сперматозоидов в Научном центре акушерства, гинекологии и перинатологии им. акад. В.И. КулаковаExperience in the use of docosahexaenoic acid (BrudiPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and PerinatologyПоповаА. Ю.PopovaA. Yu.alina-dock@ya.ruГамидовС. И.GamidovS. I.ОвчинниковР. И.OvchinnikovR. I.УшаковаИ. В.UshakovaI. V.ГолубеваО. Н.GolubevaO. N.Отделение андрологии и урологии ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России; Россия, 117997, Москва, ул. академика Опарина, 4; Кафедра акушерства, гинекологии, перинатологии и репродуктологии ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России; Россия, 117997, Москва, ул. академика Опарина, 4РоссияDepartment of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia; Department of Obstetrics, Gynecology, Perinatology and Reproductology, Faculty of Postgraduate Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, RussiaRussian FederationОтделение андрологии и урологии ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России; Россия, 117997, Москва, ул. академика Опарина, 4;РоссияDepartment of Urology and Andrology, Acad. V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology Ministry of Health of Russia; 4 akademika Oparina St., Moscow, 117997, Russia;Russian Federation2015130820151625155Copyright © Попова А.Ю., Гамидов С.И., Овчинников Р.И., Ушакова И.В., Голубева О.Н., 20152015Попова А.Ю., Гамидов С.И., Овчинников Р.И., Ушакова И.В., Голубева О.Н.Popova A.Y., Gamidov S.I., Ovchinnikov R.I., Ushakova I.V., Golubeva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/146

Почти в половине браков причиной бесплодия является мужской фактор. У бесплодных мужчин доля сперматозоидов с нарушением целостности ДНК более 30 %, при этом у здоровых фертильных мужчин – менее 15 %. С распространением вспомогательных репродуктивных технологий растет осознание важности повреждения ДНК спермы. На сегодняшний день эти последствия еще не изучены, а имеющийся терапевтический эффект от приема антиоксидантов не имеет прямой корреляции с уровнем фрагментации ДНК спермы. Докозагексаеновая кислота относится к наиболее ценным для здоровья человека полиненасыщенным жирным кислотам омега-3. Докозагексаеновая кислота – главный компонент серого вещества мозга, сетчатки глаза, яичек, спермы и клеточных мембран. В связи с этим было проведено исследование, целью которого явилась оценка влияния нутрицевтической энзиматической докозагексаеновой кислоты триглицерида (БрудиПлюс) в высокой концентрации на поврежденную ДНК сперматозоидов у пациентов с патозооспермией. В данное исследование были включены 40 больных с идиопатической патозооспермией и с уровнем фрагментации ДНК, который превышал нормативные значения. Были получены положительные результаты: прием БрудиПлюс позволяет снизить уровень повреждения ДНК сперматозоидов, а также улучшить антиоксидантную систему спермы. 

Male factor is the reason of infertility in almost half of marriages. Infertile men have the percentage of sperm with violations of DNA integrity of over 30 %; with that, healthy fertile men have that indicator of less than 15 %. Understanding of importance of damages of sperm DNA is growing with distribution ofauxiliary reproductive technologies. As of today, these consequences have not been studies yet, and the therapeutic effect of intake of antioxidants has not direct correlation with the sperm DNA fragmentation level. Docosahexaenoic acid is one of the most valuable omega-3 polyunsaturated fatty acids for human health. Docosahexaenoic acid is the main component of the brain gray matter, retina, testes, and sperm cell membranes. In connection with that, a study was held the purpose of which was to assess the effect of the nutraceutical enzymatic docosahexaenoic acid triglyceride (BrudiPlus) in high concentrations on damaged sperm DNA of patients with idiopathic pathozoospermia. 40 patients with idiopathic pathozoospermia and the level of DNA fragmentation over the statutory value took part in this study. The following positive results were received: intake of BrudiPlus allowed decreasing sperm DNA damages and improving of antioxidant system of sperm. 

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The authors declare that there are no conflicts of interest present.