agxАндрология и генитальная хирургияAndrology and Genital Surgery2070-97812412-890210.17650/2070-9781-2014-3-16-25agx-103Research ArticleОБЗОРНЫЕ СТАТЬИREVIEWВозможность получения сперматозоидов у мужчин с немозаичной формой синдрома Клайнфельтера в программах экстракорпорального оплодотворения. Обзор литературы и описание случаяMicrodissection testicular sperm extraction in patients with non-mosaic Klinefelter syndrome in programme in vitro fertilization: literature review and cases reportВитязеваИрина ИвановнаVityazevaI. I.

Москва

Moscow

vitiazeva@yandex.ruБоголюбоваС. В.BogolyubovS. V.

Москва

Moscow

vitiazeva@yandex.ruБрагинаЕ. Е.BraginaYe. Ye.

отдел электронной микроскопии Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского

Department of Electron Microscopy, A.N. Belozersky Research Institute of Physicochemical Biology

vitiazeva@yandex.ruАрифулинЕ. А.ArifulinYe. A.

отдел электронной микроскопии Научно-исследовательского института физико-химической биологии им. А.Н. Белозерского

Department of Electron Microscopy, A.N. Belozersky Research Institute of Physicochemical Biology

vitiazeva@yandex.ruФГБУ «Эндокринологический научный центр» Минздрава РоссииРоссияEndocrinology Research Center, Ministry of Health of RussiaRussian FederationФГОУ ВПО «Московский государственный университет им. М.В. Ломоносова»РоссияM.V. Lomonosov Moscow State UniversityRussian Federation2014051220141531625Copyright © Витязева И.И., Боголюбова С.В., Брагина Е.Е., Арифулин Е.А., 20142014Витязева И.И., Боголюбова С.В., Брагина Е.Е., Арифулин Е.А.Vityazeva I.I., Bogolyubov S.V., Bragina Y.Y., Arifulin Y.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://agx.elpub.ru/jour/article/view/103

Описаны современные методы обследования, предоперационной подготовки и хирургического лечения бесплодия у мужчин с немозаичной формой синдрома Клайнфельтера (СК) путем извлечения тестикулярных сперматозоидов методом микродиссекции. Мужчины с СК, реагирующие на гормональную терапию ингибиторами ароматазы и хорионическим гонадотропином человека (ХГЧ), имеют больше шансов на благоприятный исход лечения бесплодия. Объем яичек, уровень тестостерона и результаты теста с ХГЧ являются важными прогностическими факторами у данной группы пациентов. Приведен клинический случай попытки лечения бесплодия у мужчины с СК методом микрохирургической экстракции сперматозоидов из ткани яичка (микроТЕСЕ).

The article describes modern methods of examination, preoperative preparation and surgical treatment of infertility in men with non-mosaic form of Klinefelter syndrome (SK) by microdissection method of testicular sperm retrieval. Men with SK responsive to hormonal therapy with aromatase inhibitors and human chorionic gonadotropin (НCG), have a greater chance of a favourable outcome of infertility treatment. Testicular volume, testosterone levels and test results with НCG are important prognostic factors in this group of patients. We present a clinical case of treatment of infertility in men with SK by microTESE (microdissection testicular sperm extraction).

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The authors declare that there are no conflicts of interest present.